Yalong Li, Zefeng Deng, Jie Tan
Aug 21, 2023
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Journal
Asian Journal of Organic Chemistry
Abstract
This study reported Iridium‐catalyzed monofluoroalkylation of various (hetero)arenes. Diethyl 2‐bromo‐2‐fluoromalonate was identified as an effective monofluoroalkylating reagent in iridium‐catalyzed C‐H functionalization. A wide variety of monofluoride‐containing compounds were directly synthesized with moderate to good yields. Additionally, the products contained 1,3‐dicarbonyl skeletons that were easily convertible in various reactions, highlighting the synthetic importance of this method.