Jiang Da-hon
2015
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Journal
Fine chemicals
Abstract
Morpholine was found to be an effective catalyst for the synthesis of 3-acetyl coumarin through Knoevenagel condensation of 2-hydroxybenzaldehyde with ethyl acetylacetate. The influence of reaction conditions,including solvent,base,catalyst loading,and reaction time,on the yield of the target product was investigated. The results show that,under ultrasonic condition,2-hydroxybenzaldehyde reacted with ethyl acetylacetate in ethanol at room temperature catalyzed by morpholine and Na2CO3,giving 3-acetyl coumarin after 20 min in 91% yield. The product was characterized by means of NMR and IR. A plausible catalytic mechanism was also proposed.