Jinsong Zhang, Hongjuan Lu, Xufang Wang
Oct 1, 2008
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Influential Citations
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Quality indicators
Journal
Biological Trace Element Research
Abstract
The biological profile of sodium selenosulfate, Na2SeSO3, is still largely unknown. The present study found that sodium sulfite reacted with elemental selenium at nanoparticle size already at 37°C to yield sodium selenosulfate. Additionally, selenosulfate was obtained by mixing sodium selenite, glutathione, and sodium sulfite at room temperature. In vitro, sodium selenosulfate killed HepG2 or Caco2 cells, in a dose-dependent fashion, and 12.5 μM fully suppressed their proliferation. In addition, sodium selenosulfate showed a consistent cytotoxic effect when added to three kinds of leukemia cell lines (HL60, T lymph adenoma, and Daudi).