Gaoyan Lian, F. Lin, Jin Yu
Nov 8, 2008
Citations
0
Influential Citations
5
Citations
Journal
Synthetic Communications
Abstract
Abstract A novel and convenient one-pot synthesis of trimethyl 3,5,5-piperidonetricarboxylate was reported. Cocatalyzed by Yb(OTf)3 and AgOTf under mild conditions, a piperidone containing a β-amino acid template was synthesized from dimethyl malonate and formaldehyde O-benzyl oxime in high yield. It could be a useful building block for the synthesis of multisubstituted piperidine derivatives.