Rustam T. Iminov, A. Mashkov, Ivan I. Vyzir
Feb 1, 2015
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0
Influential Citations
23
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Journal
European Journal of Organic Chemistry
Abstract
Acylation of tert-butyl 3-(methylamino)but-2-enoate with fluorinated acetic acid anhydrides occurred at the enamine carbon atom. The reaction of the resulting tert-butyl 3-(methylamino)-2-(RFCO)but-2-enoates with alkyl hydrazines resulted in mixtures of isomeric pyrazoles that were easily separated by column chromatography. The target fluorinated pyrazole-4-carboxylic acids were obtained on a multigram scale.