Cong Li, P. Winnard, T. Takagi
Nov 3, 2006
Citations
0
Influential Citations
53
Citations
Journal
Journal of the American Chemical Society
Abstract
The conjugate of bacterial cytosine deaminase (bCD) and poly-l-lysine (PLL) that was functionalized with biotin, rhodamine, and Gd3+-DOTA was synthesized and characterized. It demonstrated high relaxivity, improved enzymatic specificity to prodrug 5-fluorocytosine, low cytotoxicity, efficient cell uptake, and high enzymatic stability in fresh mouse serum and human breast cancer cell culture.