S. Belman, W. Troll, G. Teebor
Mar 1, 1968
Citations
1
Influential Citations
74
Citations
Quality indicators
Journal
Cancer research
Abstract
N -Hydroxy-1-aminonaphthalene ( N -hydroxy-1-AN), N -hydroxy-2-aminonaphthalene ( N -hydroxy-2-AN), 1-aminonaphthalene (1-AN), 2-aminonaphthalene (2-AN), and 2-amino-1,4-naphthoquinone were repeatedly injected i.p. into rats at a dose of 5 mg/100 gm. Lower doses of 2-amino-1-naphthol (0.15 mg/100 gm), and of N -hydroxy-aniline (1.3 mg/100 gm) were also given i.p. N -Hydroxy-1-AN was a more potent carcinogen than N -hydroxy-2-AN; the other compounds were not notably carcinogenic. The mutagenicity of N -hydroxy-1-AN and N -hydroxy-2-AN was demonstrated in several mutants of Escherichia coli . The greater carcinogenicity of N -hydroxy-1-AN, a metabolite of 1-AN, as compared with N -hydroxy-2-AN suggests that N -hydroxylation is by itself an insufficient metabolic step in the formation of a proximate carcinogen.