K. Rasmussen, G. Booth, Milton L. Lee
Sep 1, 1991
Citations
1
Influential Citations
13
Citations
Journal
Environmental Toxicology and Chemistry
Abstract
Eight hydroxylated carbazoles and dibenzothiophenes were tested for mutagenic activity using the CHO/HGPRT mutation assay for thioguanine resistance. All showed increased activity over carbazole and dibenzothiophene. Some of the hydroxycarbazoles showed slightly higher activity than the corresponding hydroxy-dibenzothiophenes (71.4 ± 5.2 mutants/106 survivors for 1-hydroxycarbazoles compared to 21.8 ± 6.1 mutants/106 survivors for 4-hydroxydibenzothiophene at 5 μg/ml, and 32.8 ± 3.3 mutants/106 survivors at 5 μg/ml for 4-hydroxycarbazole as compared to 16.4 ± 0.9 mutants/106 survivors for 1-hydroxydibenzothiophene at 5 μg/ml). The most mutagenic compound was 1-hydroxycarbazole, which also exhibited cytotoxicity. The relative order of mutagenic activity of the hydroxycarbazoles was 1 ≥ 4 > 2 = 3 > carbazole, and the relative activity of the hydroxydibenzothiophenes was 2 ≥ 3 > 1 = 4 > dibenzothiophene. Overall, the mutagenic activity of the hydroxycarbazoles and hydroxydibenzothiophenes was dependent on the structural position of the hydroxy group.