Songyun Zhu, E. Zeiger
1993
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0
Influential Citations
14
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Quality indicators
Journal
Environmental and Molecular Mutagenesis
Abstract
The cytotoxicity and mutagenicity of the human carcinogen, treosulphan, and its hydrolysis product, dl‐1,2:3,4‐diepoxybutane (DEB), were studied in Chinese hamster ovary, AS52, cells. Treosulphan (0.1–1.0 mM) is toxic and mutagenic at the gpt locus. A strong pH dependence was noted. DEB is cytotoxic and mutagenic at a much lower dose (0.025 mM), but these effects were not affected by pH. The results suggest that the toxic and mutagenic effects of treosulphan are mediated by its hydrolysis product DEB, and that the conversion of treosulphan to DEB is highly pH‐dependent. © 1993 Wiley‐Liss, Inc.