E. Zeiger, D. Pagano
1989
Citations
0
Influential Citations
15
Citations
Journal
Environmental and Molecular Mutagenesis
Abstract
The human carcinogen treosulphan was mutagenic in Salmonella typhimurium TA100 and TA1535, as was dl‐1,2:3,4‐diepoxybutane (DEB), a proposed hydrolysis product of treosulphan. Another proposed hydrolysis product, methane‐ sulfonic acid, was not mutagenic in these strains. The pattern of the mutagenic responses at pH 6, 7, and 8 to treosulphan and DEB suggests that DEB formation may be responsible for the mutagenicity of treosulphan.