H. de Bont, J. V. van Boom, R. Liskamp
1990
Citations
0
Influential Citations
11
Citations
Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
N, N-diisopropyl-bis(4-chlorobenzyl) phosphoramidite is an easily accessible phosphitylating agent, which readily phosphorylates Boc-Ser-OMe, Boc-Thr-OMe and Boc-Tyr-OMe in good to high yields after t-BuOOH or MCPBA oxidation. The Boc-group can be removed without affecting the phosphate 4-chlorobenzyl groups and vice versa. Extension of the Boc-deprotected phosphoamino acids with a subsequent amino acid yields the corresponding protected phosphopeptides