M. Taton, P. Benveniste, A. Rahier
Jul 31, 1986
Citations
0
Influential Citations
37
Citations
Journal
Biochemical and Biophysical Research Communications
Abstract
Summary N-|(1, 5, 9)-trimethyl-decyl)|-4α, 10-dimethyl-8-aza-trans-decal-3β-ol 9 was designed to mimic the C9 or C8 high energy carbocationic intermediates postulated during the enzymic cyclization of 2,3-oxidosqualene to different triterpenes. The structurally new molecule 9 inhibits strongly cycloartenol and lanosterol cyclases in maize seedlings and rat liver microsomes respectively, whereas it does not inhibit β-amyrin cyclase in the plant system. For the first time 2,3-oxidosqualene cycloartenol cyclase and β-amyrin cyclase have been differentiated in the same plant material by use of a specific inhibitor.