Kamaljit Singh, D. Arora, Elizabeth Poremsky
May 1, 2009
Citations
0
Influential Citations
53
Citations
Journal
European journal of medicinal chemistry
Abstract
It has been found that selective N1-alkylation of 3,4-dihydropyrimidine-2(1H)-ones can be achieved under solvent-less, mild phase transfer catalytic (PTC) conditions with tetrabutylammonium hydrogen sulfate and 50% aqueous NaOH as the catalyst and base, respectively. The procedure is tolerant to substitutional variation at key diversity points on the pyrimidinone moiety.