P. Dauban, S. Ferry, H. Faure
Sep 1, 2000
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Influential Citations
31
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
The synthesis and calcimimetic properties of N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 microM) produced 97+/-11% of the maximal stimulation of [3H]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR.