Michael R. Mannion, S. Raeppel, S. Claridge
Dec 1, 2009
Citations
0
Influential Citations
45
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of N-(4-(6,7-disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting c-Met and VEGFR2 tyrosine kinases was designed and synthesized. The compounds were potent against these two enzymes with IC(50) values in the low nanomolar range in vitro, possessed favorable pharmacokinetic profiles and showed high efficacy in vivo in several human tumor xenograft models in mice.