Hyeung‐geun Park, J. Choi, Sea-hoon Choi
Feb 9, 2004
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Influential Citations
24
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Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of N-4-substituted-benzyl-N'-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG neurons. Their structure-activity relationship reveals that not only the two oxygens and amide hydrogen of sulfonamido group, but also the optimal size of methyl in methanesulfonamido group play an integral role for the antagonistic activity on vanilloid receptor.