Anil Chikkulapalli, Sanjeev Kumar Aavula, Rifahath Mona NP
Jun 10, 2015
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Dimethylacetamide (DMAc) acts as an efficient source of acetyl and dimethylamine gas in the presence of N , N -carbonyldiimidazole (CDI). Addition of amines to the reaction mixture delivers the corresponding amides in good to excellent yields. The acetylation of amines reported herein, which relies on the in situ generation of N -acetylimidazole on warming of DMAc with CDI at 120–125 °C, serves as a convenient alternative to other acetylation methods.