Bharat Gadakh, Jenny Pouyez, J. Wouters
Apr 1, 2015
Citations
0
Influential Citations
3
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The antibiotic fosmidomycin (3a) is an inhibitor of the non-mevalonate pathway for isoprenoid biosynthesis. Four analogues in which an acylated sulfonamide group is substituting for its phosphonate moiety have been synthesized in a fruitless effort to preserve one negative charge in order to increase the accompanying affinity for 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), the fosmidomycin target enzyme.