Xue-Qiang Chu, Shun‐Yi Wang, S. Ji
May 14, 2013
Citations
0
Influential Citations
10
Citations
Journal
RSC Advances
Abstract
An efficient sodium hydrogen sulfate catalyzed alkylation of indoles or amines with tertiary enamides has been accomplished in water, affording the pharmacologically and biologically active 2-oxo-1-pyrrolidine derivatives in moderate to excellent yields. The key to our success is the use of NaHSO4 as a low loading, inexpensive, green and recyclable catalyst and the reactions could be scaled up to gram level.