Xi Chen, Yang Xu, Huanrong Li
Jul 1, 2017
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0
Influential Citations
30
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Journal
Sensors and Actuators B-chemical
Abstract
Abstract Ascorbic acid (AA) plays an essential role in biochemical processes, as a scavenger for preventing oxidative damage. Although various optical measurement strategies for AA detection have been developed, there is an increasing demand for a multi-modal sensor to obtain detailed information. Herein, we propose a facile ion-exchange/coordination strategy for the preparation of a magnetic resonance (MR)/fluorescence nanohybrid by using laponite (Lap) as a matrix and Eu(DPA) 3 /Gd(DPA) 3 (DPA = Pyridine-2, 6-dicarboxylic acid) as a bimodal signal source. This nanohybrid was observed to have a higher MR response than Gd−DPA, because Gd−DPA was coordinated with Lap to affect proton relaxation parameters, while excellent Eu−DPA fluorescence remained. Moreover, potential applications of the nanohybrid had been extended to transparent films and MR/fluorescent inks. Interestingly, the MR/fluorescence of this nanohybrid was simultaneously suppressed by AA. We found that this decrease was attributed to a synergistic effect of acidity and redox. The MR/fluorescence bimodal detection of Eu(DPA) 3 /Gd(DPA) 3 @Lap makes it as a potential biological probe for clinical applications and commercialization because of its simple preparation procedure, excellent MR/fluorescence properties, high sensitivity, and high selectivity.