Cameron W. Evans, H. Viola, Diwei Ho
Sep 10, 2012
Citations
0
Influential Citations
10
Citations
Journal
RSC Advances
Abstract
Lomerizine is a calcium channel blocker that selectively blocks L- and T-type Ca2+ channels, but it is effectively insoluble under physiological conditions. Herein we show that lomerizine can be released from a nanoparticle-based carrier by intracellular protonation in PC12 cells, suppressing Ca2+ influx in these cells in response to glutamate.