K. Prabakaran, F. Nawaz Khan, J. Jin
Mar 1, 2012
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Journal
Research on Chemical Intermediates
Abstract
The 1,2,3-triazoles are versatile synthetic intermediates of many biologically active compounds, and their N-1 substituted analogues are potential pharmaceutically important derivatives. In this study, an efficient regioselective N-alkylation reaction of methyl-1H-1,2 3-triazole-4-carboxylate 3 with alkyl halides 4 catalyzed by ZnO nanoparticles in the presence of potassium hydroxide as base and DMSO as solvent is reported which leads to methyl N1-alkylated 1,2,3-triazole-4-carboxylates 5 in good yields.