R. N. Brogden, R. M. Finder, P. Sawyer
2012
Citations
0
Influential Citations
27
Citations
Quality indicators
Journal
Drugs
Abstract
SummarySynopsis: Naproxen 2, (+)-6-methoxy-α-methyl-2-naphthalene acetic acid, is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis.Published data suggest that in rheumatoid arthritis, naproxen 500mg daily is comparable in efficacy with moderate doses of aspirin (3.6 to 4g daily) or 150mg daily of indomethacin, but generally causes fewer and milder side-effects than these drugs at the dosages used and can be given less frequently (12-hourly). Encouraging initial results have been reported from its use in other inflammatory joint disorders, including acute gout and juvenile rheumatoid arthritis. It has compared favourably with indomemacin in osteoarthrosis of the hip or knee. Its exact place in the management of ankylosing spondylitis remains to be determined.