A. Kwast, Karolina Stachowska, Adam Trawczyński
Nov 30, 2011
Citations
0
Influential Citations
29
Citations
Journal
Tetrahedron Letters
Abstract
N-Aryl-2-nitrosoanilines, available from the reaction of nitroarenes with anilide anions, undergo cyclization to furnish substituted phenazines. The reaction is promoted by potassium carbonate in methanol, N,O-bis(trimethylsilyl)acetamide (BSA) in aprotic solvents, and by acetic acid. The method is illustrated by the synthesis of 1-methoxyphenazine, a precursor of pyocyanine, starting from the appropriate nitroarene–aniline pairs.