D. Maeda, W. Williams, W. Kim
Feb 11, 2002
Citations
1
Influential Citations
30
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
To delineate the differences between the structural requirements necessary for recognition at sigma-1 and sigma-2 receptors, a range of phenethyl- and phenylpropylpiperidines were evaluated in binding assays. Phenethylpiperidines were found to favor sigma-1 receptors, whereas phenylpropylpiperidines tend to favor sigma-2 receptors. It appears that phenylpropylamine is a potential pharmacophore for selective sigma-2 ligands.