J. Mahadlek, W. Sajomsang, T. Phaechamud
Dec 1, 2014
Citations
0
Influential Citations
0
Citations
Journal
Advanced Materials Research
Abstract
The objectives of research were to synthesize N-benzyl chitosan and to investigate N-benzyl chitosan on the properties of in situ forming gel such as viscosity, syringeability, drug release and antimicrobial activity against Porphyromonas gingivalis. N-benzyl chitosan was synthesized and determined by FTIR. The increased amount of N-benzyl chitosan apparently increased the viscosity and syringeability of this system. N-benzyl chitosan gel could prolong the release of doxycycline hyclate and showed the antimicrobial activity against Porphyromonas gingivalis. N-benzyl chitosan systems could be delivered from syringe through needle for periodontitis treatment.