Taiga Yurino, Yusuke Aota, Daisuke Asakawa
Jun 30, 2016
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron
Abstract
Abstract We developed a facile and practical synthesis of N -Boc-aminals, which can be used as precursors for less accessible N -Boc-imines. Aminals were obtained via simple dehydration condensation reactions of t -butyl carbamate (BocNH 2 ) and various aldehydes in acetic anhydride, followed by filtration and washing with hexane. The obtained N -Boc-alkynylaminals could be successfully applied in enantioselective Mannich-type reactions, catalyzed by chiral phosphoric acids, to afford optically active propargylamine derivatives.