Hongli Ruan, Jingyuan Zhang, Sai Sun
2017
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of Organic Chemistry
Abstract
A N-bromosuccinimide (NBS) promoted procedure for the synthesis of coumarin-3-carboxylic acids via Knoevenagel-intramolecular cyclization cascade reaction of Meldrum’s acid with various 2-hydroxyarylaldehydes has been developed. Using the mixture of water and ethanol as solvent, employing inexpensive NBS as the catalyst, and reacted at room temperature are found to highly applicable to get a satisfactory outcome. This approach expands the method for the preparation of coumarin-3-carboxylic acids and also provides other features such as mild reaction conditions, tolerant the substrates with diverse functional groups, simple workup procedure and easy isolation.