Rui-Fang Wu, Bingduo Zhou, Wen-qiong Wang
Apr 10, 2021
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Fitoterapia
Abstract
A phytochemical study performed on Inula japonica led to isolation of a new 1,10-so-sesquiterpene dimer Neolinulicin A (1) and 1,10-seco-sesquiterpene Neolinulicin B (2), together with nine known sesquiterpenes (3-11). Among them, Neolinulicin A (1), which has a new carbon skeleton, was a Diels-Alder [4 + 2] adduct of two sesquiterpene moieties. Their structures were established by extensive spectroscopic analysis. All of the isolated compounds showed inhibition of NO production in RAW 264.7 macrophages. The findings might supply information for the future design of anti-inflammatory agents from I. japonica.