P. Manberg, G. Bissette, C. Nemeroff
Feb 1, 1978
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Neuropharmacology
Abstract
Neurotensin (NT), an endogenous brain tridecapeptide, produces hypothermia after intracerebroventricular administration in rats and mice. The hypothermie potency of a series of structural analogues of neurotensin has been studied. [d-Arg9]-NT, NT9–13 and physalemin were devoid of hypothermie activity. The most potent peptides studied in reducing body temperature of cold-exposed rats were bombesin and [d-Tyr11]-NT. [d-Arg8]-NT, [Phe11]-NT, [d-Pro7]-NT, NT-MHMe [d-Pro10]-NT and NT8–13 possessed significant hypothermie activity, though the latter two compounds were the least active. These results indicate that the C-terminal end of the neurotensin molecule is essential for hypothermie activity.