Ashok Kumar, M. Tyagi, V. Srivastava
Sep 1, 2003
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0
Influential Citations
10
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Quality indicators
Journal
ChemInform
Abstract
A series of 3-(substitutedarylidene)hydrazinoacetylamino-2-methyl-6-bromo-quinazolin-4(3H)-ones 4a-e has been prepared by the condensation of 3-(hydrazinoacetylamino)-2-methyl-6-bromoquinazolin-4(3H)-one 3 with different aromatic aldehydes. Compounds 4a-e on treatment with chloro-acetylchloride in the presence of triethylamine are converted into 3-[2'-(substituted-aryl)-3'-chloro-4'-oxo-1'-azetidinyl] aminochloroacetylamino-2-methyl-6-bromoquinazolin-4(3H)-ones 5a-e, which undergo Mannich reaction to yield compounds 6a-e. The structures of all the new compounds have been confirmed by elemental analysis and spectral studies (IR, 1 H NMR and mass spectroscopy). Compounds 4a-4e, 5a-5e and 6a-6e have been evaluated for hypotensive activity and were found to exhibit activity ranging from 10-90 mmHg. The most active compound of this series is 3-[2'-(p-N-N-dimethylaminobenzylidine))-3'-chloro-4'-oxo-1'-azetidinyl-aminoacetylamino]-2-[(p-methoxyphenyl)aminoethyl]-2-methyl-6-bromoquinazo-lin-4(3H)-one 6d which has shown blood pressure lowering activity of 90 mmHg, which lasted for 120 min. at a dose of 2.5 mg/kg i.v.