R. Ramage, Jeremy Green
1987
Citations
0
Influential Citations
78
Citations
Quality indicators
Journal
Tetrahedron Letters
Abstract
A new acid labile protecting group for the guanidino side chain functionality of arginine has been developed. NG-(2,2,5,7,8-Pentamethyl-chroman-6-sulphonyl)-L-arginine, prepared from Nα-benzyloxycarbonyl-L-arginine and 2,2,5,7,8-pentamethylchroman-6-sulphonyl chloride, is cleaved rapidly in trifluoroacetic acid (TFA) or 50% TFA in dichloromethane at room temperature.