Jinghua Tang, Pei Liu, Xiaoming Zeng
Aug 16, 2018
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Influential Citations
15
Citations
Journal
Chemical communications
Abstract
Described here is a chromium-catalyzed alkylative cross-coupling of benzamide derivatives with aliphatic electrophiles under mild conditions. This reaction was promoted by a low-cost and air-stable chromium(iii) chloride salt combined with an N-heterocyclic carbene ligand and phenylmagnesium bromide as a reductant, and probably occurred with low-valent chromium involved in the catalytic cleavage of the ortho-C-H bonds of the benzamide, followed by coupling with the alkyl bromide through a radical-involving mechanism.