E. Miller, J. Miller, H. A. Hartmann
Jul 1, 1961
Citations
3
Influential Citations
360
Citations
Quality indicators
Journal
Cancer research
Abstract
Summary N-Hydroxy-2-acetylaminofluorene, a major metabolite of 2-acetylaminofluorene in the rat, was more active than the parent amide in producing tumors in the liver, mammary gland, small intestine, and the ear duct of the rat. In addition, the N-hydroxy metabolite induced many papillomas and squamous-cell carcinomas of the fore-stomach when given in the diet. When injected intraperitoneally it produced a variety of multiple sarcomas in the peritoneum. 2-Acetylaminofluorene was inactive at the latter two sites. Dietary 3-methylcholanthrene, which is a potent inhibitor of carcinogenesis by 2-acetylaminofluorene, dif not inhibit the carcinogenicity of N-hydroxy-2-acetylaminofluorene. These data provide strong evidence that N-hydroxy-2-acetylaminofluorene is one of the proximate agents in carcinogenesis by 2-acetylaminofluorene in the rat.