Meredith S Eno, Alexander J Lu, J. Morken
Jun 16, 2016
Citations
0
Influential Citations
30
Citations
Journal
Journal of the American Chemical Society
Abstract
Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive SN2-like oxidative addition of a nickel complex to the electrophilic substrate.