N. S. Cutshall, R. Ursino, K. Kucera
Jul 23, 2001
Citations
2
Influential Citations
28
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.