Alain Steiner, J. Mayer, B. Testa
Sep 1, 1992
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0
Influential Citations
10
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
Abstract— Nicotinate esters were studied for their binding to, and hydrolysis by, human serum albumin. Some esters (ethyl, isopropyl, t‐butyl, cyclohexyl, benzyl) were bound but not hydrolysed, while others (2‐chloroethyl, 2‐butoxyethyl) displayed the opposite behaviour; 1‐carbamoylethyl ester was neither bound nor readily hydrolysed. Only p‐methoxyphenyl nicotinate was both a ligand and a substrate, and its rate constants of binding and hydrolysis were calculated in a stepwise procedure using a kinetic model.