Feb 7, 2020
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Abstract
T he hydrochloride salt of nilotinib, an orally bioavailable aminopyrimidine-derivative BcrAbl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Ablmediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. T his agent also inhibits the receptor tyrosine kinases plateletderived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GIST s). With a binding mode that is energetically more favorable than that of imatinib, nilotinib has been shown to have an approximately 20-fold increased potency in kinase and proliferation assays compared to imatinib. Qeios · Definition, February 7, 2020