H. Ahankar, A. Ramazani, Yavar Ahmadi
Jul 1, 2013
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Journal
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
Abstract Reactions of N-isocyaniminotriphenylphosphorane (Ph3PNNC) with aromatic bis-aldehydes (isophthalaldehyde and terphthalaldehyde) in the presence of 3-phenyl-2-propynoic acid and secondary amines proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed. GRAPHICAL ABSTRACT