R. Fuller, H. Snoddy, K. Perry
Oct 1, 1979
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Influential Citations
11
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Journal
Neuropharmacology
Abstract
Abstract Nisoxetine hydrochloride (5–40 mg/kg i.p.) antagonized the depletion of norepinephrine in brain and heart following the injection of α -methyl- m -tyrosine (6.25–100 mg/kg, s.c.) into rats and mice. In rats. the degree of antagonism was directly related to the dose of nisoxetine and inversely related to the dose of α -methyl- m -tyrosine. Associated with the antagonism by nisoxetine of norepinephrine depletion by α -methyl- m -tyrosine was a reduction in the tissue concentration of metaraminol, the metabolite of α -methyl- m -tyrosine whose retention in nerve terminals probably accounts for the depletion of norepinephrine. Similar antagonism of norepinephrine depletion and lowering of metaraminol concentration by nisoxetine was observed in brain and heart after the injection of metaraminol itself. These findings extend previous data showing the effectiveness of nisoxetine as an inhibitor of uptake into norepinephrine neurons in vitro .