C. Pramanik, K. Bapat, P. Patil
May 9, 2019
Citations
1
Influential Citations
4
Citations
Journal
Organic Process Research & Development
Abstract
An efficient, short manufacturing process for fenspiride hydrochloride is reported. Nitro-aldol condensation is the key reaction in the developed process. Improved routes to key building blocks are demonstrated by expedient multikilogram production. Hazardous reactions are avoided. API produced following this new route meets the quality requirement NLT 99.70% purity by HPLC with any individual impurity NMT 0.10% with very good yield.