C. D. Risi, S. Benetti, M. Fogagnolo
Jan 23, 2013
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
An unprecedented domino Michael/α-alkylation reaction between 2,5-dihydrothiophene-3-carbaldehydes and bromonitromethane is presented. This process, efficiently catalyzed by DL-proline in the presence of MeOH/NaOAc system, provides access to novel 6-nitro-3-thiabicyclo[3.1.0]hexane-1-carbaldehyde derivatives in good yields with good to excellent diastereoselectivities.