John D. Roberts, G. Sullivan, P. P. Pang
Feb 1, 1981
Citations
0
Influential Citations
1
Citations
Journal
Journal of Organic Chemistry
Abstract
5-Azacytidine (4-amino-1-β-D-ribofuranosyl-1,3,5-triazin- 2(1H)-one, 1) has been investigated for its potential in leukemia therapy, based on the finding, inter alia, that mRNA containing 5-azacytidylic acid residues is unable to function correctly in protein synthesis. The compound is also of interest for comparison of its ^(15)N NMR characteristics with those of cytidine (2), especially with regard to assignments of chemical shifts, differentiation between the N4' protons, degree of restricted rotation about C4N4', and site of protonation of the ribonucleoside.