J. Casado, M. Quintela, M. Mosquera
Dec 1, 1983
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Abstract
This article reports a kinetic study of the nitrosation of morpholine (MOR) by the nitroprusside ion, [Fe(CN)5NO]2−, to form N-nitrosomorpholine, a substance of proven carcinogenicity. The reaction is of order one with respect to the nitroprusside ion and order two with respect to morpholine. The influence of the pH and the ionic strength of the medium on the rate of reaction has been studied in detail. A reaction mechanism is proposed whose first step is a fast reaction between the amine and the coordinated nitrosyl group to form a complex which reaches equilibrium with the reagents and then reacts with another molecule of amine to produce the corresponding nitrosamine and the complex [Fe(CN)5MOR]3−. The acidity constant of morpholine has been determined kinetically.