Sha-Hua Huang, Xuechao Tian, Xia Mi
Dec 2, 2015
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron Letters
Abstract
Abstract In this communication, a nitroso-ene cyclization was devised to rapidly construct 1-azaspiro[4.4]nonane, a key structural motif which was further implemented into the modular synthesis of (±)-cephalotaxine ( 6 ). The whole synthesis route to access the key intermediate 7 involves eight steps from a commercially available 1,2-epoxycyclopentane ( 12 ) and five purifications on silica gel column. The direct nitroso-ene reaction to 1-azabicyclo[4.4]non-2-one paves a way to a future development of the practical synthesis of cephalotaxus alkaloids.