S. Orkin, J. Littlefield
May 1, 1971
Citations
0
Influential Citations
59
Citations
Journal
Experimental Cell Research
Abstract
Summary Other investigatiors have shown that nitrosoguanidine (NG) preferentially mutagenizes the replication fork of bacteria and can be used to map the bacterial chromosome. The susceptibility of synchronized hamster cells to NG mutagenesis prior to and throughout the DNA synthetic period has been determined for two markers, resistance to 6-thioguanine or 5-bromodeoxyuridine. Mutagenesis in these experiments was independent of the position of the cell in the replicative cycle. This suggests a major difference in the response to NG of bacteria and animal cells.