S. Katti, K. Agarwal
1985
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Use of a novel coupling reagent, N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride (BOPDC) in the synthesis of oligodeoxyribonucleotides is described. This reagent allows the synthesis of phosphotriesters in high yields (70–80%) without detectable side reactions. Synthesis of a hexanucleotide, d(A-A-C-C-C-G) is presented as an example.