R. Carter
1977
Citations
0
Influential Citations
42
Citations
Journal
Journal of Clinical Pathology
Abstract
IARC has held biennial working conferences on the analysis and formation of N-nitroso compounds since 1969. The most recent publication in the series presents a large group of original papers collected into four sections. The first covers methods of analysis of volatile and nonvolatile compounds; the latter continue to present extremely difficult analytical problems. The second section is concerned with formation of N-nitroso compounds, discussing nitrosation reactions in vitro and in vivo and their catalysis and inhibition. Certain drugs may be an unsuspected source of secondary and tertiary amines which can be converted into nitrosamines. The third section deals with the sources and distribution of N-nitroso compounds in materials such as tobacco smoke, meat products, fish and air and water. The levels recorded continue to fall into the ,ug/kg range and are difficult to appraise in terms of potential carcinogenic hazard. The last section contains miscellaneous contributions on general toxicology and carcinogenesis. There are useful concluding summaries and recommendations for future work. The book appears to be well edited but, like its predecessors in the series of LARC scientific publications, it would be easier to use if it contained an index.