S. Makhseed, M. Macháček, Waleed Alfadly
Nov 5, 2013
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Influential Citations
122
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Quality indicators
Journal
Chemical communications
Abstract
Newly synthesized zinc phthalocyanine bearing sixteen quaternized imidazolyl moieties on the periphery displays high water-solubility, lack of aggregation and high singlet oxygen quantum yield in water (ΦΔ > 0.33). The in vitro tests indicated excellent anticancer photodynamic activity (EC50 = 36.7 nM) and low dark toxicity to non-cancerous cells (TC50 = 395 μM).