B. R. Baker, R. Patel, P. I. Almaula
Nov 1, 1963
Citations
0
Influential Citations
8
Citations
Journal
Journal of pharmaceutical sciences
Abstract
5-(Bromoacetyl)salicylic acid (XII) irreversibly inhibits glutamic dehydrogenase and lactic dehydrogenase about as well as the standard exoalkylating agent, 4-(iodoacetamido) salicylic acid, at one-tenth the concentration of the standard; most of this increased reactivity is because of the higher reactivity of the halogen in XII. Three of the four iodoacetamido compounds that reversibly bound to lactic dehydrogenase more tightly than the standard gave irreversible inhibition at 10-20 per cent the concentration necessary for the standard. Three carbophenoxyamino heterocyclic acids showed no irreversible inhibition of lactic dehydrogenase, but were effective irreversible inhibitors of glutamic dehydrogenase at one-tenth the concentration of the standard compound.